Andrew Maniotis, Ph.D.

Program Director in the Cell and Developmental Biology of Cancer

Departments of Pathology, and Bioengineering,

University of Illinois at Chicago, Chicago, IL 60607

Pre-Graduate Education and Research:

1980-1983. A. B., Physical anthropology. Laboratory focus: human osteology.

Professors Stephen Molnar, Robert Sussman, directors.

Department of Anthropology, Washington University, St. Louis, MO.

1983-1985. Research Technician, Laboratory focus: neuroexitotoxicity, and developmental neurobiolgy. Dr.John Olney, and Dr. Richard Bunge, directors. McDonnell Center For Higher Brain Function, Departments of Psychiatry, Anatomy Cell Biology, Washington University School of Medicine, St. Louis, MO.

1985-1986. Research Technician, Laboratory focus: muscle development. Professor Richard Strohman, director. Department of Zoology, University of California , Berkeley CA .

Graduate Education and Postgraduate Research:

1986-1991. Ph.D., Cell biology, Laboratory of cytoskeletal biology. Professor Manfred Schliwa, director and graduate advisor. Departments of Zoology, Cell and Molecular Biology, University of California , Berkeley , CA .

1991-1992. NIH-Post-Doctoral Fellow in Cell Biology, Cell Biology Group,

Dr. Thoru Pederson, director. Worcester Foundation For Experimental Biology, Shrewsbury , MA .

1992-1997. Fellow in Surgical Research, Laboratory of tumor angiogenesis,

Dr. Donald Ingber, Post-Doctoral Advisor, Dr. Judah Folkman, director.

Department of Surgical Research and Pathology, Harvard Medical School , Boston MA .

1997-2000. Research Scientist, Department of Anatomy and Cell Biology, and the

Iowa Cancer Center, Mary Hendrix, director, University of Iowa, Iowa City, IA.

2000-2007. Assistant Professor of Pathology, Anatomy and Cell Biology, and Adjunct Prof. of Bioengineering. Program director of The Cell and Developmental Biology of Cancer, University of Illinois , Chicago , Chicago IL . 60612.

Honors, lectures, awards :

1988. Stipend For Evolutionary studies, Museum of Vertebrate Zoology, University of California, Berkeley CA. 1990.

1992. USDA Fellowship in the Molecular Biology of Insect Viruses, Department of Entomological Sciences, University of California, Berkeley, CA.

1994. Zum Thema Wissensbank Honorarium.

1995. Invited speaker, Gordon Confererence on "The Biological Basis of Cell and Tissue Structure and Function", Copper Mountain, CO.

1997. Work presented by "The Second Annual Videoconference On Space Station Research", NASA.

1997. Work presented by The Faraday Society.

1998. Work presented by "The Penrose-Hameroff Colloquium."

1998. Work cited by The Royal Society, London.

1999. Invited Lectureship:Biological Physics Colloquium, Banff, Canada.

2000. Research Colloquium Lectureship on Integrins, Madison, WI.

2000. Earnest Orlando Lawrence Berkeley National Laboratory Lectureship, Berkeley, CA.

2001 . Physicochemical processes in biological systems in space overstudy panel report.

2002. Nomination for Bodossaki Foundation Award, Athens, Greece.

2003. Who's who in American Science; 2003-2005.

2003. Invited Speaker: Gordon Conference on Polyamines, New London, CT.

2003. Invited Speaker: FASEB conference Chromatin Structure and Cancer, Saxon Rivers, VT.

2005. Lectureship Colloquium on Polyamines, Cellgate, Pharmaceuticals, Redwood City, CA.

2005. First and second place winner, Health and Medicine Engineering, UIC., Chicago , IL .

2006. TREC Accelerator Award Recipient on Viral Assays, National Center For Supercomputing Applications, Champaign-Urbana, IL. http://www.trecc.org/accelerator/awardees.htm

Other Activities: Invited Member of The Boston Vascular Task Force, Children's hospital, Boston MA . 1995-1997, Judah Folkman, director.

Study section(s): Ad Hoc Grant Reviewer: “Therapeutic Modulation of Angiogenesis in Disease.” NCI, 1998-9. Invited member: “APA, Screening Technologies Branch DTP, DCTD, NCI.” Fall 2000.

Reviewer: American Journal of Physiology, Journal of Cellular Biochemistry, Investigative Ophthalmology and Visual Science, FACEB Journal, American Journal of Pathology, PNAS, British Medical Journal, Medical Veritas, and others.

Reseach Programs and Goals: Cancer therapeutics through microenvironment manipulation; vaccine adjuvants and cancer; tensegrity modeling; biochemical reconstruction of chromosomes; viral assay development; mechanogenomics, biofilm biology, oncolytic therapy of cancer, genome evolution, immune suppression and cancer.

Publications:

1)---Clifford, DB.,Olney, J.W.,Maniotis, A.,Collins, RC., Zorumski, CF. The functional anatomy and pathology of Lithium-Pilocarpine and high dose pilocarpine seizures. Neuroscience Vol 23 (3): pp.953-968, 1987.

2)---Strohman, R.C., Bayne, E., Spector,D., Obinata,T., Micou-Eastwood, J., Maniotis A. Myogenesis and histogenesis of skeletal muscle on flexible membranes. In Vitro Cell Dev. Biology, Vol 26: pp. 201-208, 1990.

3)---Maniotis, A., Schliwa, M. Microsurgical removal of centrosomes blocks cellular reproduction and centrosome regeneration in BSC-1 cells. Cell, Vol. 67 pp.201-208, 1991.

4)---Schutze, K., Maniotis, A., Schliwa, M. The position of the microtubule-organizing center in directionally migrating fibroblasts depends on the nature of the substratum. Proc. Nat. Acad. Sci. Vol. 88 pp. 8367-8371, 1991.

5)---Ingber,D. Dike, L., Hansen, L., Karp, S., Liley, H., Maniotis, A., McNamee, H., Mooney, D., Sims, J., Wang, N. Cellular tensegrity: exploring how mechanical changes in the cytoskeleton regulate cell growth, migration, and tissue pattern during morphogenesis. Int Rev Cytol. 150:173-224,1994.

6)---Maniotis, A., Chen, C., Ingber, D. Demonstration of mechanical interconnections between integrins, cytoskeletal filaments, and nuclear scaffolds that stabilize nuclear structure. Proc. Nat. Acad. Sci . Vol. 94 pp.849-854, 1997.

7)---Maniotis, A., Bojanowski, K., Ingber, D. Mechanical continuity and reversible chromosome disassembly within intact genomes removed from living cells. J. Cellular Biochem. Vol 65: 114-130, 1997.

8)---Bojanowski, K., Maniotis, A., Ingber, D. DNA toposiomerase ll can control chromatin topology and drive chromosome condensation without enzymatically modifying DNA. J. Cellular Biochem. Vol. 69:127-142,1998.

9)---Eckes, B., Dogic, D., Colucci-Guyon, E., Wang, N, Maniotis, A., Ingber, D., Merckling, A., Aumailley, M., Delouvee, M., Koteliansky, V., Babinet, C., Krieg, T. Impaired mechanical stability, migration, and contractile capacity in vimentin-deficient fibroblasts. J. Cell Science Vol. 111: 1897-1907, 1998.

10)---Eckes, B.; Martin, P.; Smola, H.; Dogic, D.; Colucci-Guyon, E.; Maniotis, A.;Wang, N.; Aumailley, M.; Ingber, D.; Babinet, C.; Krieg, T Disruption of tensegrity in vimentin-deficient fibroblasts causes delayed wound healing in fetal and adult mice. J. of Dermatol. Sci. Vol: 16, Issue: 1001, pp. 120., 1998.

11)---Pourati J, Maniotis A, Spiegel D, Schaffer JL, Butler JP, Fredberg JJ, Ingber DE, Stamenovic D, Wang N. Is cytoskeletal tension a major determinant of cell deformability in adherent endothelial cells? Am. J. Physiol. May; 274 ( 5 Pt 1):C1283-C1289, 1998.

12)---Chen, C. Ingber, D, and Maniotis A. A Strategy for Research in Space Biology and Medicine In the New Century. Physiology, Gravity, Space, Chapter 6, 1998.

13)---Goldman, WF.,Alonso JL, Bojanowski, K.,Bragwynne, C., Chen C.S., Chirchurel, M.E., Dike, L.,Huang, S., Lee, K-M., Maniotis, A., Mannix, R.,McNamee, H.,Meyer, C., Naruse, K, Parker, K.K., Plopper, G., Polte, T., Wang, N., Yan, L., Ingber, D.E. Cell shape Control and Mechanical Signaling Through the Cytoskeleton. The Cytoskeleton and Signaling: A Practical Approach. Chapter 11, 1999.

14)---Maniotis A., Folberg R., Hess A., Seftor E., Gardner L., Pe’er J., Trent J., Meltzer P., Hendrix M. Vascular channel formation by human uveal melanoma cells in vivo and in vitro: Vasculogenic mimicry. Amer. J. Path. Vol. I55, No 3, pps. 739-752, September, 1999.

15)---Katherine Verdolini, Steven Zeitels, Andrew Maniotis, Rosemary Desloge, Robert Hillman. Role of Mechanical Stress in Tissue Recovery Subsequent to Acute Phonotrauma. Speech-Language. Path., June, 1999.

16)---Robert Folberg, Mary Hendrix, and Andrew Maniotis. Vasculogenic Mimicry and Tumor Angiogenesis. American Journal of Pathology, Vol 156, No.2, 2000.

17)---Michael A. Warso, Andrew Maniotis, Xue Chen, Dibyen Majumdar, Niu K. Patel, Anne Shilkaitis, tapas K. Das Gupta, Robert Folberg. Prognostic Significance of Vasculogenic mimicry patterns in primary cutaneous melanoma. Clin Cancer Res. Mar;7(3):473-7, 2001.

18)---Folberg R, Chen X, Boldt HC, Pe’er J, Brown CK, Woolson RF, Maniotis AJ: Microcirculation patterns other than loops and networks in choroidal and ciliary body melanomas. Ophthalmology, 98:996-1001, 2001.

19)---Andrew Maniotis, Xue Chen, Christopher Garcia, Phillip J. DeChristopher, Ding Wu, Jacob Pe’er, Robert Folberg. Control of Melanoma Morphogenesis Endothelial Survival, and Perfusion By Extracellular Matrix. Lab Investigation. Vol. 82 No. 8 p.1083-1092, 2002.

20)---A. Mueller, A. Maniotis, W. Freeman, D. Bartch, U.Schaller, G.Bergeron-Lynn, L. Cheng, Taskintuna, X. Chen, J. Kan-Mitchell, R. Folberg. An orthotopic model for human uveal melanoma in SCID mice. Microvasc Res Vol. 44, 2002.

21)---Chen X, Maniotis AJ, Majumdar D, Pe'er J, Folberg R: Uveal melanoma cell staining for CD34 and the assessment of tumor vascularity. Invest Ophthalmol Vis Sci. Aug; 43(8): 2533-9, 2002.

22)---Seftor EA, Meltzer PS, Kirschmann DA, Pe'er J, Maniotis AJ, Trent JM, Folberg R, Hendrix MJ. Molecular determinants of human uveal melanoma invasion and metastasis. Clin Exp Metastasis, 19(3) 233-46, 2002.

23)---Chen X, Ai Z, Rasmussen M, Bajcsy P, Auvil L, Welge M, Leach L, Vangveeravong S, Maniotis AJ, Folberg R. Three-dimensional reconstruction of extravascular matrix patterns and blood vessels in human uveal melanoma tissue: techniques and preliminary findings. Investigative Ophthalmology and Visual Science. 44:2834-2840, 2003.

24)---Richard Gordon, John Karavitis, Jonas Moses, Klara Valyi-Nagy, and Andrew Maniotis. Differentiation waves versus positional information of morphogen gradients: which is cause and effect? Information Processing in Cells and Tissues, Morphomechanics of the Embryo and Genome, Lausanne , Switzerland , 2003.

25)--- Robert Folberg, Jacob Pe’er, Andrew J. Maniotis. Extravascular Matrix Patterns in Uveal Melanoma: Histogenesis, Structure, and Molecular Regulation. In: Uveal Melanoma: A model for Exploring Fundamental Cancer Biology. Swets & Zeitlinger, Publishers, 2004.

26)---Eleni Papadopulos-Eleopulos, Valendar F Turner, John Papadimitriou, Barry Page, David Causer, Helman Alfonso, Sam Mhlongo, Todd Miller, Andrew Maniotis, Christian Fiala. A critique of the Montagnier evidence for the HIV/AIDS hypothesis. Med Hypotheses. 63(4):597-601, 2004.

27)---Folberg R, Maniotis A. Vasculogenic mimicry. Acta Pathologica Microbiologica et Immunologica Scandinavica, 112:508-25, 2004.

28)---Maniotis AJ, Valyi-Nagy K, Karavitis J, Moses J, Boddipali V, Wang Y, Nuñez R, Setty S, Arbieva Z, Bissell MJ, and Folberg R: Chromatin organization measured by Alu I restriction enzyme changes with malignancy and is regulated by the extracellular matrix and the cytoskeleton. Am J Pathol 166: No. 4 April 2005.

29)---Lin AY, Maniotis AJ, Valyi-Nagy K, Majumdar D, Setty S, Kadkol S, Leach L, Pe'er J, Folberg R.Distinguishing fibrovascular septa from vasculogenic mimicry patterns. Arch Pathol Lab Med. Jul;129(7):884-92, 2005.

30)---Kadkol SS, Lin AY, Barak V, Kalickman I, Leach L, Valyi-Nagy K, Majumdar D, Setty S, Maniotis AJ, Folberg R, Pe'er J. Osteopontin expression and serum levels in metastatic uveal melanoma: a pilot study. Invest Ophthalmol Vis Sci. Mar;47(3):802-6, 2006.

31)---Maniotis Andrew, Maniotis Rita, Joseph Espat N. Joseph; Chen Xue, Lycos Peter. Why is the Hepatitis B vaccine still mandated? Medical Veritas, Nov; 3(2):1206-1210, 2006.

32)--- Folberg R, Arbieva Z, Moses J, Hayee A, Sandal T, Kadkol S, Lin AY, Valyi-Nagy K, Setty S, Leach L, Chevez-Barrios P, Larsen P, Majumdar D, Pe'er J, Maniotis AJ.
Tumor cell plasticity in uveal melanoma: microenvironment directed dampening of the invasive and metastatic genotype and phenotype accompanies the generation of vasculogenic mimicry patterns. Am J Pathol. Oct;169(4):1376-89, 2006.

33)---Tone Sandal, Klara Valyi-Nagy, Robert Folberg, Mina Bissell, Virginia Spensor, Andrew Maniotis. Epigenetic reversion of breast carcinoma phenotype and DNA sequestration. American Journal Of Pathology, Vol. 170(5):1739-49. May, 2007.

34)---Klara Valyi-Nagy, Robert Folberg, Tibor Valyi-Nagy, Andrew J. Maniotis. Susceptibility of Herpes simplex Virus Type I and II, The Role of Tumor Invasiveness, The Extracellular Matrix, and Chromatin Sequestration. In press, May, Experimental Eye Research, Vol. 84, 9991-10,000, 2007.

35)--- Lin AY, Ai Z, Lee SC, Bajcsy P, Pe'er J, Leach L, Maniotis AJ, Folberg R. Comparing vasculogenic mimicry with endothelial cell-lined vessels: techniques for 3D reconstruction and quantitative analysis of tissue components from archival paraffin blocks. Appl Immunohistochem Mol Morphol. Mar;15(1):113-9, 2007.

36)---Folberg R, Leach L, Valyi-Nagy K, Lin AY, Apushkin MA, Ai Z, Barak V, Majumdar D, Pe'er J, Maniotis AJ. Modeling the behavior of uveal melanoma in the liver. Invest Ophthalmol Vis Sci. 2007 Jul;48(7):2967-74.

37)---. Barak V, Frenkel S, Kalickman I, Maniotis AJ, Folberg R, Pe'er J. Serum markers to detect metastatic uveal melanoma. Anticancer Res. Jul-Aug;27(4A):1897-900, 2007.

38)--- Barak V., Frenkel S., Valyi-Nagy K., Leach L., Apushkin MA., Lin A., Kalickman I., Baumann N., Pe’er J., Maniotis A., Folberg R. Using the direct-injection model of early uveal melanoma hepatic metastasis to identify TPS as a clinically useful serum biomarker. Invest Ophthalmol Vis Sci. Oct;48(10):4399-402, 2007.

39)---Papadopulos-Eleopulos E, Page BA, Causer D, Turner VF, Papadimitriou JM, Maniotis A.Cancer and epigenetic reversion the fundamental role of redox. Am J Pathol. Nov;171(5):1726-7, 2007.

40)---Grace Guzman, Scott J. Cotler, Amy Y. Lin, Robert Folberg, Andrew J. Maniotis. Expression of vasculogenic mimicry correlates with earlier hepatocellular carcinoma recurrence after orthotopic liver transplant. Archives Lab. Medicine, Vol. 131, p 56-61, 2007.

--Tone Sandal, Klara Valyi-Nagy, Amin Hayee, Laurence J Marton, and Andrew J Maniotis. Sensitivity of metastatic cells to polyamine analogs is accompanied by DNA sequestration and is dependent upon cellular phenotype. Submitted.

--Andrew Maniotis, Lynn Margulis. From genophores to chromosomes, submitted.

--Lynn Margulis, Andrew Maniotis, James MacAllister, John Scythes, John Hall . Resurgence of “The Great Imitator"? Submitted.

On-line publications:

Doctors for Disaster Preparedness. Vaccines and Epidemics. How to Predict Epidemics.
http://www.ddponline.org/vande.htm

A Brief History of AIDS http://barnesworld.blogs.com/barnes_world/2006/12/a_brief_history.html

A Global Strategy Against "AIDS" Demands Evidence Not Emotion. http://barnesworld.blogs.com/barnes_world/2007/01/a_global_strate.html

The 48 diseases that are AIDS. http://64.233.167.104/search?q=cache:eLxwWOuthgIJ:barnesworld.blogs.com/48AIDS.pdf+maniotis&hl=en&ct=clnk&cd=23&gl=us

Some expert critiques of primary work:

-Work on cancer:

---Science, September 3rd, 1999. “New type of blood vessel found in tumors.” p1475.

---The Lancet, Sept. 13, 1999. “Tumors find another way to feed themselves.” p2.

---Amer. J. Path., September, 1999, “Tumor plasticity allows vasculogenic mimicry, a novel form of angiogenic switch.” pps. 675-679.

---Focus, Number 38, 20 September, 1999 . Nahung fur den Krebs. Cover story.

---Chicago Tribune, September 17, 1999. "Cancer Theory is Questioned." Front page.

---College of American Pathologists, 2000. "Eyeing a new path for tumor growth." Feature story.

---New Scientist: 11 Sept, 1999 . "Organized Killers," p11.

---Science, Vol. 287, 4 Feb. 2000. “Face-off over tumor blood supply,” pps. 783-4.

---Nature Medicine, Volume 6 Number 4 April 2000. “Mechanisms of angiogenesis and arteriogenesis”, p. 392.

---The Lancet Oncology Vol 3 January 2002. Melanoma–stroma interactions: structural and functional aspects. p35-43.

---Basic Pathology, W B Saunders Co. Current 2004 Edition. In: Neoplasia; "Vasculogenic mimicry in Uveal melanomas." V Kumar, R S Cotran and S L Robbins. Am J Pathol. 2005

---Apr;166(4):959-62. Review. Mechanogenomic control of DNA exposure and sequestration. Stein GS.

---DNA 'Packaging' Linked with Cancer; National Review of Medicine (Canada). " MAY 15, 2005, VOLUME 2 NO. 9. "Protein markers flag cancer cells that are impervious to chemo."

---Canadian Online Pharmacy Journal: Genomic DNA provides clues to new advances in cancer diagnostics Medical Research News 22-Mar-2005.

---Epigenetic reversion of breast cancer DNA.

http://www.eurekalert.org/pub_releases/2007-04/ajop-bcm042607.php

-Work on cytoskeletal mechanics, tensegrity, and genomics:

---Science ,Vol 276, 1997, pp 678-679; “Force-Carrying Web Pervades Living Cell.”.

---Annu. Rev. of Physiol., 1997 Vol. 59: 575-99. “Tensegrity: The Architectural Basis of Cellular Signal Transduction.”

---Scientific American,. January, 1998, pp48-57, “The Architecure of Life.”

---Biochem. Cell Biol., 79: 267–274 (2001). “The integration of tissue structure and nuclear function.”

-Work on centrosomes and cellular microsurgury:

---Nature, Vol 355, 1992, pp300-301. “Centrosome and Cell Division.”

---Current Opinions in Cell Biology, Vol 2, Number 5, 1992, pp.243-245. “Double or Nothing.”

Inventions:

1. Title: Chromosome stability assay
United States Patent 20050079516 (http://www.freepatentsonline.com/20050079516.html)
Abstract:
Embodiments of the invention relate to compositions and methods for evaluating or estimating the invasive potential of cells and thereby differentiating between normal and cancerous cells in accordance with the susceptibility of the cellular chromatin to degradation or other modification by particular enzymes or agents. Chromatin within permeabilized normal and non-invasive cells, including chromatin strands removed there from, are more susceptible to degradation by endonucleases or proteinases than is the chromatin from invasive cells.

2 .Title: Methods and compositions related to a matrix chip
United States Patent Application No.425/MUMNP/2006 (http://www.tmpsearchers.com/Patdatabase/2007April20/pg_0116.htm) Abstract:
Embodiments of the invention relate to devices and methods for evaluating the interactions between cells and between cells and matrix materials wherein the cellular distribution pattems formed as a result of such interactions are indicators of the invasive potential(s) of the cells. Furthermore, such devices and methods can provide indications of the preferred sites of metastasis of invasive cells; the efficacy of an anti-cancer drug applied to such cells; and the potential for agents to promote or enhance tumor growth or metastasis.

3. Title: Constricting gel assay and therapeutic patch
International Application No. PCT/US2006/013672
(http://www.wipo.int/pctdb/en/wo.jsp?wo=2006110827)
Abstract: Method and compositions relate diagnostic tools to determine invasive potential of tumor cells. Therapeutic patches include a component from the extracellular matrix seeded with tumor cells from an individual and a fibrin backing. Extracellular matrix-based constriction assays are useful to screen for anti-tumor compounds.

4. Title: Methods for determining the pathogenicity of viral strains
Application No. PCT/US2006.035258
(http://www.wipo.int/pctdb/en/wo.jsp?wo=2007030815 )
Abstract
Methods and compositions are provided for rapidly detecting the presence and lytic potential of a pathogenic virus in a sample and for determining the pathogenicity of a viral strain to cells, as compared to merely detecting the presence of viruses in a sample. Assays determine the pathogenicity of viral strains based on the viral strains’ ability to expose nuclease sites on the host cell’s nuclear DNA (e.g. condensed chromatin in malignant cells (to a DNA nuclease).

Teaching Experience:

Spring, 1983. Instructor: “Osteology”. Department of Anthropology, Washington University, St. Louis, MO.

Fall, 1986, Spring, 1987. Instructor: “Biology 1A, 1B”. Department of Zoology, University of California, Berkeley, CA.

Fall, 1988, Lecturer: “Cytogenetics" 110, Department of Zoology, University of California , Berkeley CA .

Spring, 1989.Lecturer: "Cytogenetics Laboratory”. Department of Zoology, University of California , Berkeley CA .

Fall, 1989. Instructor, “Molecular Cell Biology”. Department of Molecular Biology, University of California , Berkeley CA .

Spring, 1990. Course Coordinator and Instructor: “Molecular Cell Biology 130” . Department of Molecular Cell Biology, University of California , Berkeley , CA .

May, 1991. Instructor: “Advanced Quantitative Light Microscopy”. Woods Hole, MA.

Fall 1997-8. Research Scientist. “Cell Biology”, graduate course. Department of Biochemistry. University of Iowa Medical College, Iowa City , IA.

Fall 2000. Assistant Professor of Pathology. Bioengineering 1A. Department of Bioengineering, University of Illinois, Chicago, Chicago, IL.

Spring, 2000. Assistant Professor of Pathology. “Cell Biology”. Department of Physiology and Biophysics. University of Illinois, Chicago, Chicago, IL.

Fall 2001. Assistant Professor of Pathology. “Pathology for 2 nd Year Medical students”. Department of Pathology. University of Illinois , Chicago, Chicago IL .

Fall 2001. Assistant Professor of Pathology. “Graduate Course in Microbiology”. Department of Microbiology. University of Illinois, Chicago, Chicago, IL.

Spring, 2002. Assistant Professor of Pathology. “Cell Biology”. Department of Physiology and Biophysics. University of Illinois, Chicago, Chicago, IL.

Fall, 2002. Assistant Professor of Pathology. “Pathology for 2 nd Year Medical Students. Department of Pathology, University of Illinois, Chicago, IL.

Spring, 2003. Assistant Professor of Pathology. “Cell Biology”. Department of Physiology and Biophysics. University of Illinois, Chicago, Chicago, IL.

Fall, 2004. Assistant Professor of Bioengineering. Senior Design Course. Department of Bioengineering, University of Illinois , Chicago, Chicago IL .

Spring, 2004. Assistant Professor of Bioengineering. Senior Design Course. Department of Bioengineering, University of Illinois , Chicago, Chicago IL .

Graduate or post-graduate level students at UIC:

* 2001-2003-Viveka Boddipalli. Developed a project in my lab at UIC involving differential chromatin stability assays. Currently, Mr. Boddipalli has been admitted into the CDC's program of Public Health.

* 2001-2003. Ms. Ding Wu. Developed a project to quantify gel contraction weights of malignant versus non-malignant tumor cells in my lab at UIC. Currently she is at The University of Chicago obtaining a PhD.

* 2001-2003. Mr. John Karavitis, Developed a chromatin isolation assay in my lab at UIC. Currently he has completed course work toward his Ph.D. at Harvard, and has returned to Chicago to complete his PhD at Loyola Medical School.

* 2001-2002. Mr. Christopher Garcia. Graduated while in my lab. Developed a project to obtain cells lacking nuclei to access howthey could construct simple tissues in the absence of transcription. Currently, he is working for Charles Rivers as a biological model provider.

* 2002-2003, 2006. Mr. Jonas Moses. Developed an extracellular matrix assay (“bio-chip”). Currently he is leading the project on discovering mechanisms and therapeutic limitations for the use of polyamines in cancer and has completed his doctorate in the lab. Currently, he is doing a post-doctoral fellowship at Argon National Laboratories in Chicago.

* 2005. Amin Hayee. Developing a new extracellular matrix model f tumor invasion and dormancy. Currently, he is in the residency program at UIC.

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