WAVE - Specific Vaccines Pertussis (whooping cough)

Specific Vaccines
Pertussis (whooping cough)

Pertussis (whooping cough) Information

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Pertussis (whooping cough) Vaccines

Acel-Immune Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed

Manufacturer	Lederle Laboratories
Microorganism	The bacterial toxins C. diphtheriae and C. tetani and acellular pertussis adsorbed
Licensed	12/30/1996
Recommendations	Immunizations for Infants and Children <7 Years of Age: The first three i.m. injections are usually given at ages 2, 4 and 6 months, the fourth dose at age 15-18 months, and the fifth dose at age 4-6 years. The fifth dose is not necessary if the fourth dose was given after the child's fourth birthday. Immunizations for Children 7 or More Years of Age, Adolescents, and Adults: Three injections of Td; the first two doses should be given 4-8 weeks apart and the third dose 6-12 months after the second. Thereafter, routine booster doses of Td should be given every 10 years.
Ingredients	Aluminum hydroxide, Formaldehyde, Gelatin, Polysorbate 80, Thimerosal, Pertussis toxin, Aluminum phosphate, Diphtheria toxoid, Tetanus toxoid.
Product Descriptions	http://www.whale.to/vaccines/ingredients1.html http://www.fda.gov/cber/efoi/approve.htm
Acel-P Pertussis

Manufacturer	Wyeth-Ayerst
Microorganism	The bacterial toxin of B. pertussis
Licensed	New product in 2001, original license 1996
Recommendations	3 i.m. injections at 0, 6, 12 weeks (but not more than 10 weeks) in children 15 months to 6 years of age
Ingredients	Aluminum hydroxide, Gelatin, Polysorbate 80, Thimerosal, Pertussis toxin, Filamentous hemagglutinin (FHA), Aluminum phosphate.
Product Descriptions	Corporate package insert: http://www.vran.org/vaccines/dpt/dptr-acelp-wyeth-98-to-01.htm
Adacel™ Tetanus, reduced diphtheria toxoids, acelular pertussis, adsorbed (TdaP)

Manufacturer	Sanofi Pasteur
Microorganism	The bacterial toxins of C. dipthriae, C. Tetani, and B. Pertussis
Licensed	01/23/2006
Recommendations	One i.m. injection for use in 11-64 year old persons.
Ingredients	Formaldehyde, Glutaraldehyde, 2 - Phenoxyethanol, Pertussis toxin, Filamentous hemagglutinin (FHA), Aluminum phosphate, Diphtheria toxoid, Tetanus toxoid.
Product Descriptions	University: http://www.vaccinesafety.edu/components-Tdap.htm Manufacturer Press Release http://www.fda.gov/cber/efoi/approve.htm
Boostrix™ (Tdap) Tetanus toxoid, reduced diphtheria toxoid and acellular pertussis, adsorbed

Manufacturer	GlaxoSmithKline
Microorganism	The bacterial toxins B. pertussis, C. tetani, C. diphtheriae
Licensed	12/29/2005
Recommendations	For use in 10-18 year old persons; Single 0.5 mL i.m. injection route into the deltoid muscle of the upper arm.
Ingredients	Formaldehyde, Latex, Polysorbate 80, Filamentous hemagglutinin (FHA), Pertactin, Aluminum adjuvant.
Product Descriptions	Package Insert http://www.fda.gov/cber/products/tdapgla050305.htm http://www.fda.gov/cber/efoi/approve.htm
Certiva™ (DTaP) Diphtheria and tetanus toxoids and acellular pertussis vaccine, adsorbed

Manufacturer	North American Vaccine, Inc.
Microorganism	The bacterial toxins of C. diptheriae, C. tetani, and B. pertussis.
Licensed	07/29/1998
Recommendations	From 6 to 7 weeks, begin 3 i.m. injections at 2, 4, and 6 months of age, intervals of 6-8 weeks, with a fourth dose at 15-20 months, interval between 3rd and 4th doses should be at least 6 months.
Ingredients	Ammonium sulfate, Aluminum hydroxide, Formaldehyde, Thimerosal, Pertussis toxin, Diphtheria toxoid, Tetanus toxoid, Bovine (cow) serum, Fetuin.
Product Descriptions	Certiva FDA Document http://www.fda.gov/cber/efoi/approve.htm
DAPTACEL (DTaP)

Manufacturer	Sanofi Pasteur
Microorganism	The bacteria C. diphtheriae, C. tetani, B. pertussis
Licensed	2002
Recommendations	4 injections at 2, 4, 6 months, and 17-20 months of age.
Ingredients	Formaldehyde, Glutaraldehyde, Latex, 2 - Phenoxyethanol, Pertussis toxin, Pertactin, Aluminum phosphate, Diphtheria toxoid, Tetanus toxoid.
Product Descriptions	Package Insert
DPT Merieux (DTPer/Vac/Ads) Adsorbed diphtheria tetanus and pertussis vaccine BP, Pasteur Mérieux

Manufacturer	Pasteur Mérieux
Microorganism
Licensed
Recommendations	Three injections with an interval of at least 4 weeks between the first and second doses and at least 4 weeks between the second and the third doses. The vaccine may be administered to infants from 2 months of age.
Ingredients
Product Descriptions	http://whale.to/vaccines/dtp_merieux.htm
DTAP-IPV Poliomyelitis

Manufacturer	Statens Serum Institute
Microorganism	C. diphtheriae, C. tetani, B. purtussis, polio virus, haemophilus influenzae type B virus
Licensed	01/29/1999
Recommendations	Usually administered to babies at two, three and four months of age.
Ingredients	Diphtheria toxoid, Tetanus toxoid, Virus: polio, Haemophilus influenzae B.
Product Descriptions	http://www.healthscotland.org.uk/immunisation/dtap_ipv_1/index.cfm http://www.immunisation.nhs.uk/article.php?id=39 http://www.pei.de/cln_048/nn_160996/EN/drugs/impfstoffe-am-en/polio-en/polio-node-en.html?__nnn=true
DTCOQ/DTP Adsorbed Diphtheria, Tetanus, Pertussis Vaccine

Manufacturer	Aventis
Microorganism
Licensed
Recommendations	start at two months of age, 3 injections at one or two month intervals
Ingredients	Aluminum hydroxide, Thimerosal, Diphtheria toxoid, Tetanus toxoid.
Product Descriptions	Package Insert
Hexavac (DTaP, IPV, HBV, Hib) Diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis, hepatitis B (recombinant) and Haemophilus influenzae type b conjugate vaccine, adjuvanted

Manufacturer	Aventis Pasteur MSD
Microorganism	C. Diphtheriae, C. tetani, B. pertussis, polio virus, hepatitis B and Haemophilus influenzae type b
Licensed	10/26/2000
Recommendations	One i.m. injection for infants (from 2 to 12 months of age) with booster vaccination in toddlers (from 12 to 18 months of age).
Ingredients	Aluminum hydroxide, Formaldehyde, Sucrose, Pertussis toxin, Filamentous hemagglutinin (FHA), Diphtheria toxoid, Tetanus toxoid, Bovine (cow) serum, Sodium hydroxide, Virus: Hepatitis B, Medium 199, Haemophilus influenzae B, Acetic acid, Trometamol, Sodium hydrogen carbonate, Potassium dihydrogen phosphate, Disodium phosphate dehydrate.
Product Descriptions	Suspension Press Release
Infanrix Hexa (DTaP, IPV, Hib, HBV) Diptheria, tetanus, pertussis, H. influenzae B, Hepatitis B and inactivated polio virus

Manufacturer	GlaxoSmithKline (France)
Microorganism	Diphtheria, tetanus, and pertussis toxoids, hepatitis B, Poliovirus Type 1 (Mahoney strain), Type 2 (MEF-1 strain), Type 3 (Saukett strain)
Licensed	10/26/2000
Recommendations	Three i.m. injections at 2, 3, 4 months.
Ingredients	Aluminum hydroxide, 2 - Phenoxyethanol, Pertussis toxin, Filamentous hemagglutinin (FHA), Pertactin, Sodium chloride, Aluminum phosphate, Diphtheria toxoid, Tetanus toxoid, Virus: Hepatitis B, Medium 199, Virus: polio, Haemophilus influenzae B, Lactose.
Product Descriptions	EMEA Document
Infanrix® (DTaP) Diphtheria and tetanus toxoids, acellular pertussis

Manufacturer	GlaxoSmithKline
Microorganism	The bacteria C. diphtheriae, C. tetani, B. pertussis
Licensed	01/29/1997
Recommendations	For use as the initial four doses of the recommended diphtheria, tetanus, and pertussis vaccination series among children aged 6 weeks-6 years. Infanrix is also licensed for all remaining doses in the schedule for children who have received one or more doses of whole-cell DTP vaccine. Each dose of Infanrix contains 24 µg PT, 25µg FHA, 8µg Pn, 25 Lf of diphtheria toxoid, and 10 Lf of tetanus toxoid (Table 1).
Ingredients	Aluminum hydroxide, Formaldehyde, Latex, 2 - Phenoxyethanol, Polysorbate 80, Pertussis toxin, Filamentous hemagglutinin (FHA), Pertactin, Sodium chloride, Diphtheria toxoid, Tetanus toxoid.
Product Descriptions	University: http://www.vaccinesafety.edu/components-DTaP.htm
Pediacel (DTaP, IPV, HiB) Diphtheria, tetanus, five component acellular pertussis, inactivated poliomyelitis and Haemophilus influenzae type b conjugate vaccine, adsorbed

Manufacturer	Aventis Pasteur (Europe)
Microorganism	C. diptheriae, C. tetani, B. pertussis, polio virus, H. influenzae B
Licensed	10/10/2002
Recommendations	Three i.m. injections at 2, 3, 4 months with at least one month between injections.
Ingredients	Aluminum hydroxide, Formaldehyde, Glutaraldehyde, Neomycin, 2 - Phenoxyethanol, Polymyxin B, Polysorbate 80, Streptomycin, Pertussis toxin, Aluminum phosphate, Diphtheria toxoid, Tetanus toxoid, Virus: polio, Haemophilus influenzae B, Polyribosylribitol phosphate, African green monkey kidney cells.
Product Descriptions	Web site: http://www.clovelly.org.uk/documents/pediacel.html Web site: http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=15257
Pediarix™ (HBV, DTaP, IPV) and inactivated Polio

Manufacturer	GlaxoSmithKline
Microorganism	C. diphtheriae, C. tetani and B. pertussis, H. influenzae virus type b and the polio virus
Licensed	December 13, 2002
Recommendations	3 i.m. injections in infants as early as 6 weeks of age, to 7 years of age.
Ingredients	Aluminum hydroxide, Formaldehyde, Neomycin, Polymyxin B, Polysorbate 80, Thimerosal, Yeast, Pertussis toxin, Filamentous hemagglutinin (FHA), Pertactin, Stopper vial may contain dry latex rubber, Tetanus, Sodium chloride, Virus: polio.
Product Descriptions	Package Insert
Pentacel® (HiB, DPT, IPV) ActHIB® reconstituted with QUADRACEL®

Manufacturer	Aventis (Canada)
Microorganism	H. influenzae virus type b, C. diphtheriae, C. tetani, B. pertussis, and polio virus
Licensed	09/26/2005
Recommendations	4 injections at 2, 4, 6, and 18 months of age, not for use with persons age 7 or older.
Ingredients	Formaldehyde, Neomycin, 2 - Phenoxyethanol, Polymyxin B, Polysorbate 80, Pertussis toxin, Filamentous hemagglutinin (FHA), Pertactin, Aluminum phosphate, Diphtheria toxoid, Tetanus toxoid, Bovine (cow) serum, Virus: polio, Haemophilus influenzae B, Polyribosylribitol phosphate.
Product Descriptions	Package Insert
POLIAcel™ Combination vaccine pack containing Act-HIB®: Haemophilus influenzae type b polysaccharide conjugated to tetanus protein reconstituted with QUADRACEL™: Pertussis Vaccine-Acellular Combined with Diphth

Manufacturer	Aventis Pasteur
Microorganism	C. diphtheriae, C. tetani, B. pertussis, polio virus and H. influenzae virus type b
Licensed
Recommendations	primary immunisation schedule is one dose given at 2, 4 and 6 months of age. A booster dose may be given at 15 to 20 months of age
Ingredients	Formaldehyde, Glutaraldehyde, Neomycin, Polymyxin B, Polysorbate 80, Sucrose, Filamentous hemagglutinin (FHA), Aluminum phosphate, Diphtheria toxoid, Tetanus toxoid, Bovine (cow) serum, Virus: polio, Haemophilus influenzae B, Trometamol, Pertussis Toxoid.
Product Descriptions	http://www.appco.com.au/appguide/drug.asp?drug_id=00074416&t=cmi http://www.medsafe.govt.nz/profs/Datasheet/q/Quadracelinj.htm
QUADRACEL® (DTP, IPV) Diphtheria, tetanus, pertussis, adsorbed with poliomyelitis

Manufacturer	Aventis
Microorganism	C. Diphtheriae toxin, C. tetani toxin, B. pertussis, poliovirus type 1, 2, and 3
Licensed
Recommendations	4 i.m. injections at 2, 4, 6, and 18 months of age. Not recommended for those over 7 years of age.
Ingredients	Formaldehyde, Neomycin, 2 - Phenoxyethanol, Polymyxin B, Polysorbate 80, Pertussis toxin, Filamentous hemagglutinin (FHA), Pertactin, Tetanus, Aluminum phosphate, Diphtheria toxoid, Bovine (cow) serum.
Product Descriptions	Package Insert
Repavax (dTaP/IPV) Diphtheria, Tetanus, Pertussis (Acellular, Component) and Poliomyelitis (Inactivated) Vaccine, adjuvanted.

Manufacturer	Aventis Pasteur
Microorganism	C. diphtheriae, C. tetani, B. pertussis, polio virus
Licensed	09/26/2006
Recommendations	from the age of three years, as a booster
Ingredients	Formaldehyde, Neomycin, 2 - Phenoxyethanol, Polymyxin B, Polysorbate 80, Streptomycin, Pertussis toxin, Aluminum phosphate, Diphtheria toxoid, Tetanus toxoid, Virus: polio, Polyribosylribitol phosphate, African green monkey kidney cells.
Product Descriptions	http://www.clovelly.org.uk/documents/repevax.html http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=15256
SII Triple Antigen Diphtheria, Tetanus and Pertussis Vaccine Adsorbed

Manufacturer	Serum Institute of India, Ltd
Microorganism	C. diphtheria, C. Tetani, B. Pertussis
Licensed
Recommendations	3 doses should be inoculated on 3 separate occasions at 4 to 6 week intervals. The first dose should be given at approximately 6 weeks of age. Reinforcing injections should be given 12 months after the primary immunization and also between the ages of 4 to 6 years.
Ingredients	Thimerosal, Aluminum phosphate, Diphtheria toxoid, Tetanus toxoid.
Product Descriptions	http://www.seruminstitute.com/content/products/product_dtp_vac.htm
TetrACT-HIB Adsorbed diphtheria, tetanus, pertussis, and conjugated haemophilus type b vaccine

Manufacturer	Aventis Pasteur
Microorganism	C. diphtheriae, C. tetani, B. pertussis and haemophilus type b virus
Licensed
Recommendations	2 months of age, 3 injections at one or two month intervals
Ingredients	Aluminum hydroxide, Sucrose, Thimerosal, Sodium chloride, Diphtheria toxoid, Tetanus toxoid, Sodium hydroxide, Haemophilus influenzae B, Acetic acid, Trometamol, Potassium dihydrogen phosphate, Dehydrate sodium hydrogen phosphate.
Product Descriptions	Package Insert
Tetramune (DTP-HbOC) Diphtheria and Tetanus Toxoids and Pertussis Vaccine Adsorbed with Haemophilus b Conjugate Vaccine

Manufacturer	Lederle Laboratories (Canada)
Microorganism	C. diphtheriae, C. tetani, B. pertussis and Haemophilus b virus
Licensed	03/30/1993
Recommendations	(Not for individuals age 7 or older) At 6 weeks of age, the immunisation series for TETRAMUNE consists of 3 doses of 0.5 mL each at approximately 2 month intervals, followed by a fourth dose of 0.5 mL at approximately 15 months of age.
Ingredients	Formaldehyde, Thimerosal, Aluminum phosphate, Diphtheria toxoid, Tetanus toxoid, Sodium phosphate-monobasic, Sodium phosphate-dibasic dodecahydrate, Glycine, Potassium phosphate, Haemophilus influenzae B.
Product Descriptions	http://whale.to/m/tetramune.html http://www.drugs.com/cons/Tetramune.html http://www.mayoclinic.com/health/drug-information/DR202911
Tetravac® Diphtheria, tetanus, acellular pertussis and inactivated poliomyelitis vaccine, adsorbed

Manufacturer	Aventis Pasteur
Microorganism
Licensed
Recommendations	Primary immunisation can be given as 3 doses at an interval of 1-2 months starting at the age of 2 or 3 months or as 2 doses at an interval of 2 months starting at the age of 3 months and a third dose at the age of 12 months. A fourth dose should be administered within the second year of life.
Ingredients	Aluminum hydroxide, Formaldehyde, Glutaraldehyde, 2 - Phenoxyethanol, Filamentous hemagglutinin (FHA), Diphtheria toxoid, Tetanus toxoid, Sodium hydroxide, Medium 199, Virus: polio, Acetic acid, Pertussis Toxoid.
Product Descriptions	Package Insert
Tri-Immunol DPT Adsorbed

Manufacturer	Wyeth (Canada)
Microorganism	C. diphtheriae, C. tetani, B. pertussis
Licensed	07/24/1970
Recommendations	The recommended vaccination schedule is a dose at 2 months, 4 months, 6 months and 15 or 20 months with a booster dose at prior to entering school at 4-6 years of age
Ingredients	Thimerosal, Tetanus, Aluminum phosphate.
Product Descriptions	http://aolsvc.health.webmd.aol.com/drugs/drug-14929-Tri-Immunol+IM.aspx?drugid=14929&drugname=Tri-Immunol+IM http://www.vran.org/vaccines/dpt/dptr-tri-im93.htm#tri-im93
TriHIBit® DTaP and Hib conjugate

Manufacturer	Sanofi Pasteur
Microorganism	The bacterial toxins C. diphtheriae, C. tetani, B. pertussis. and Haemophilus influenzae type b.
Licensed	2001
Recommendations	One, 0.5 mL i.m. injection of vaccine.
Ingredients	Ammonium sulfate, Formaldehyde, Gelatin, Latex, Polysorbate 80, Pertussis toxin, Filamentous hemagglutinin (FHA), Aluminum potassium sulfate, Diphtheria toxoid, Tetanus toxoid, Haemophilus influenzae B.
Product Descriptions	Package Insert Note: As of May 2001, Aventis was in the process of transitioning to their new preservative-free DTaP and Hib conjugate vaccine; however, some supplies of the original TriHIBit® may still be in use. http://www.rxlist.com/cgi/generic/acthib_ids.htm
Tripacel® Pertussis Vaccine-Acellular, Combined With Diphtheria And Tetanus Toxoids (Adsorbed)

Manufacturer	Aventis
Microorganism	Pertussis, Diphtheria, Tetanus
Licensed
Recommendations	one dose administered at 2, 4 and 6 months of age, booster dose should be administered at 18 months of age, should not be administered to persons after their eighth birthday
Ingredients	Filamentous hemagglutinin (FHA), Pertactin, Aluminum phosphate, Diphtheria toxoid, Tetanus toxoid, Pertussis Toxoid.
Product Descriptions	http://www.drugs.com/cons/TRIPACEL.html http://www.medsafe.govt.nz/Profs/Datasheet/t/Tripacelinj.htm
Tripedia® DTaP

Manufacturer	Sanofi Pasteur
Microorganism	The bacteria C. diphtheriae, C. tetani, B. pertussis.
Licensed	2001
Recommendations
Ingredients	Formaldehyde, Gelatin, Polysorbate 80, Thimerosal, Pertussis toxin, Filamentous hemagglutinin (FHA), Stopper vial may contain dry latex rubber, Tetanus, Aluminum potassium sulfate.
Product Descriptions	Package Insert (Note: As of May 2001, Aventis was in the process of transitioning to their new preservative-free DTaP vaccine; however, some supplies of the original Tripedia® may still be in use.)
Triple Antigen™ Diphtheria, Tetanus and Pertussis Vaccine (Adsorbed)

Manufacturer	CSL Limited, New Zealand
Microorganism	C. diphtheriae, C. tetani, B. pertussis
Licensed
Recommendations	Triple Antigen™ should be given at 2, 4 and 6 months of age with a booster dose at 18 months of age
Ingredients	Thimerosal, Sodium chloride, Aluminum phosphate, Diphtheria toxoid, Tetanus toxoid, Sodium phosphate.
Product Descriptions	http://www.medsafe.govt.nz/profs/Datasheet/t/tripleantigenvaccineinj.htm
Tritanrix HB-HIB (DtwP, HBV, HiB) Diphtheria, tetanus, pertussis and hepatitis B

Manufacturer	GlaxoSmithKline
Microorganism	C. diphtheriae, C. tetani, B. pertussis and hepatitis B virus
Licensed	July 19, 1996
Recommendations	Single injection as early as 6 weeks of life.
Ingredients	Aluminum hydroxide, Yeast, Sodium chloride, Aluminum phosphate, Diphtheria toxoid, Tetanus toxoid, Virus: Hepatitis B.
Product Descriptions
Tritanrix HepB (DTPw+HBV) Diphtheria (D), tetanus (T), pertussis (whole cell) (Pw) and hepatitis B (rDNA) (HBV) vaccine

Manufacturer	GlaxoSmithKline
Microorganism	C. diphtheriae, C. tetani, B. pertussis and hepatitis B virus
Licensed	07/19/1996 (E.U.)
Recommendations	Three injections with an interval of at least one month between each.
Ingredients	Thimerosal, Yeast, Sodium chloride, Aluminum phosphate, Diphtheria toxoid, Tetanus toxoid, Virus: Hepatitis B, Aluminum oxide.
Product Descriptions	Consumer Package Insert Professional Package Insert
TRIVAX-AD (DT Per/Vac/Ads), Adsorbed Diphtheria, Tetanus and Pertussis Vaccine

Manufacturer	The Wellcome Foundation Limited, London
Microorganism	C. diphtheriae, C. tetani, B. pertussis
Licensed
Recommendations	Not for adults and elderly. Children up to six years: 3 injections at intervals of not less than four weeks of age.
Ingredients	Aluminum hydroxide, Thimerosal, Sodium chloride, Diphtheria toxoid, Tetanus toxoid, Sodium Borate, Succinic Acid.
Product Descriptions	http://whale.to/vaccines/dtp__trivax.htmf
Trivax-Hib Adsorbed Diphtheria, Tetanus and Pertussis Vaccine BP, DTPer/Vac/Ads (Trivax-AD®) and Haemophilus type b conjugate Vaccine

Manufacturer	GlaxoSmithKline (UK)
Microorganism	C. diphtheriae, C. tetani, B. pertussis and haemophilus influenza type b virus
Licensed
Recommendations	Three injections starting at two months of age. Children under ten years of age.
Ingredients	Aluminum hydroxide, Pertussis toxin, Tetanus toxoid, Haemophilus influenzae B.
Product Descriptions	http://whale.to/vaccines/trivax.html
Zaantide Diptheria, tetanus and pertussis vaccine, adsorbed

Manufacturer	Institute of Immunology (Croatia)
Microorganism	C. diphtheria, C. tetani, B. Pertussis
Licensed
Recommendations	Age 3-6 months; 0, 4-6 weeks, 4-6 weeks, 6 months
Ingredients	Formaldehyde, Thimerosal, Aluminum phosphate, Diphtheria toxoid, Tetanus toxoid.
Product Descriptions	Package Insert

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